<p>Nichols is listed as out due to personal reasons, narrowing the Cardinals’ interior depth and potentially increasing stress on the defensive line.</p><p>Fantasy implications center on lineup flexibility and the need for backup playmakers to step up, as Arizona seeks to maintain pressure without Nichols in the rotation.</p>

Dlineman Bilal Nichols is questionable for personal reasons after being activated from PUP; absence would force DL promotions from the practice squad to cover interior needs against the Colts.

Nichols is limited with a neck issue, adding to the interior rotation questions and the Cards’ ability to pressure the quarterback.

Nichols practiced as his PUP window opened, signaling possible activation from neck injury last year; the DL depth upgrade could shift rotation if active.

Nichols opened the return window, potentially absorbing more snaps as Nolen’s status remains unclear, elevating Nichols’ IDP and rotational upside.